Research Brings New Insights for the Treatment of Male Infertility

New research is expanding what we know about the causes, diagnosis, and treatment of infertility in men.

In one recent paper, a team from New York-Presbyterian Hospital/Weill Cornell Medical Center in New York City demonstrated the effectiveness of microsurgical sperm extraction and intracytoplasmic sperm injection (ICSI) -- techniques developed by Weill Cornell scientists -- in restoring fertility to men previously considered sterile due to Klinefelter syndrome.

And in a commentary published in the October issue of Fertility and Sterility, NewYork-Presbyterian/Weill Cornell Urologist-in-Chief and Weill Cornell Urology Chair Dr. Peter N. Schlegel compared the ease and efficacy of available sperm DNA tests.

Dr. Schlegel was also senior researcher on the study on Klinefelter syndrome, just published in the November issue of the Journal of Clinical Endocrinology & Metabolism. Both the Department of Urology and Center for Reproductive Medicine and Infertility, led by Dr. Zev Rosenwaks, collaborated on the study.

"Klinefelter syndrome affects about one in 500 or 600 men," Dr. Schlegel explained. "It occurs when the men are born with an extra X chromosome -- for reasons that are still unclear, this can dramatically lower the number of sperm in the testes. In fact, counts are so low that sperm don't leave the body, and these men were long considered sterile and untreatable."

Using a technique first described by his team in 1998 in the New England Journal of Medicine, Dr. Schlegel used microsurgery to detect viable sperm within the testes of men affected by the syndrome. Once detected, this sperm was extracted and then introduced into a mature egg using a high-tech form of in vitro fertilization called intracytoplasmic sperm injection (ICSI), previously developed by Weill Cornell scientist Dr. Gianpiero Palermo of Rosenwaks' team.

This latest study confirms the efficacy of that breakthrough technology, Dr. Schlegel said. Working with 42 men with Klinefelter syndrome, his team first used drugs called aromatase inhibitors to help boost the men's sperm production. Twenty-nine of the patients had sufficient sperm found in their testes for extraction, which were then injected into mature eggs, resulting in 18 pregnancies and 21 live births.

"The treatment allows you to use very small numbers of sperm, and it works because of surgical techniques developed here at NewYork-Presbyterian/Weill Cornell," Dr. Schlegel said. "It's given new hope to men who otherwise would never have been able to become biological fathers."