Tuesday, August 22, 2006

Fertility Center Launching Study On Egg Freezing

WEST HARTFORD, Conn. -- Women wishing to put motherhood on hold may soon have more success.

The UConn Center For Reproductive Services is launching a major study on egg freezing.

UConn already freezes sperm and embryos. But, until now, it's been hesitant to freeze unfertilized eggs because of uncertainty over the success of thawing.

The health center is testing out two freezing methods to find out which one works best.

Egg freezing is currently done at some clinics, but doctors at UConn said it's still experimental.

UConn plans to enroll about 30 couples in the study, age 36 or younger, who would otherwise discard their unused eggs.

Scientists ‘modify’ goat in Lord Krishna’s land

New Delhi: Indian scientists have been successful in genetically engineering goats, holding out the promise of the animals being reared in the country for their high milk yield and high quality meat to boost farmers’ incomes.

Krishna, a kid goat, was born at the Central Institute for Research on Goats (CIRG), Mathura, Uttar Pradesh on Thursday, a day after Janmashtami was celebrated to mark the birth of Lord Krishna in the town considered his birthplace.

The four scientists involved in the project took three years to achieve success in impregnating a nondescript breed goat with an ovum of a goat taken from an Agra abattoir and fertilised with the sperm of a Sirohi buck. “Our effort was a success as the kid is brown in colour, showing that it has inherited the Sirohi characteristics and not its foster mother’s,” said S K Jindal, principal scientist at CIRG.

The CIRG is the second institute after the Karnal-based National Dairy Research Institute (NDRI) to have successfully bred a goat kid through in-vitro fertilisation (IVF).

“Our aim through IVF is to conserve the germ-plasma of good breeds of goats and sheep and go in for genetic engineering of goats for multiple births,” said N P Singh, director, CIRG. The team is awaiting the outcome of two other Sirohi goats that have been impregnated. Further success would lead to qualitative improvement in the breeding of goats.

Wednesday, August 16, 2006

Blood test to tell you: It's now or never for a baby

Women can now find out how much time they have left to start a family with a simple blood test.

The test checks for levels of anti-Mullerian hormone (AMH) which is made by the ovaries and plays a vital part in the production of the female hormone oestrogen. It also helps the egg mature each month.

The level of AMH indicates how well the ovary is functioning and, as this falls with age, experts believe it is the best indicator of future fertility.

One in seven women in the UK now choose to become mothers beyond the age of 35 and this test could be vital for those wanting to delay motherhood but who do not want to miss their chance of becoming a mum.

The test, which is not yet available on the NHS, can also be useful to women wanting to know when they are likely to start the menopause. And it can help couples assess how likely they are to succeed at IVF because the higher the level of AMH the better quality the mother's eggs are likely to be.

'Experts now agree that AMH is one of the most accurate measures of a woman's fertility,' says Dr Ellis Downes, consultant gynaecologist and chief executive of GynaeCheck, who supply the test.

'Similar tests already available tend to check for levels of oestrogen but as these fluctuate when a woman becomes menopausal it will not be as accurate as the AMH test.'

The test kit can be ordered over the internet, but unlike similar tests available can be done at any stage in a women's cycle. The sample is then sent to a laboratory.

The results will be delivered within five days and come in a traffic light form. Green means the woman's

AMH levels are normal and that provided she has no other health issues she should have no problem conceiving for the next 12 months at least.

Amber means that levels of AMH are starting to fall and she may have problems conceiving if she delays for more than a year and red means that the levels of AMH are very low and that she may be menopausal.

The test can also be used as a marker for polycystic ovary syndrome, a hormonal condition.

¦ TAKING the contraceptive Pill may lower the risk of some cancers.

Researchers who have monitored more than 17,000 women for over 30 years have found that taking the Pill may protect against cancers of the womb and ovaries. The Oxford University researchers found that the protective effects were sustained up to 20 years after women stopped taking the Pill.

Analysis of the 844 cases of breast cancer among the women shows that the risk was about the same for Pill users and non-users. But the chances of pill users developing uterine or ovarian cancer were one tenth those of non-users.

'Beneficial effects for oral contraceptives on the gynaecological cancers outweighed adverse effects,' say the researchers, even though Pill users of more than eight years were found to be six times more likely to develop cervical cancer.

¦ THE anti-Mullerian hormone test is available from www.canigetpreg-nant.co.uk for £145 (£80 for members of the female healthcare company GynaeCheck) or call 01707 877889 for more details.

Frozen mice 'have healthy pups'

Mice kept in the deep freeze for 15 years have fathered healthy offspring, say scientists in Japan and Hawaii.

One in five female mice undergoing IVF with sperm extracted from the dead mice had healthy, fertile pups.

It offers hope to those trying to bring extinct animals back from the dead, they report in the Proceedings of the National Academy of Sciences.

One idea would be to inject frozen mammoth sperm recovered from the ice into the eggs of female elephants.

The researchers wrote: "If spermatozoa of extinct mammalian species (eg woolly mammoths) can be retrieved from animal bodies that were kept frozen for millions of years in permanent frost, live animals might be restored by injecting them into oocytes from females of closely related species."

Ice Age

The team, led by Atsuo Ogura of the Institute of Physical and Chemical Research Bioresource Center in Tsukuba, Japan, harvested sperm from intact testes and, in some cases, the entire mouse, of specimens stored at -20C for up to 15 years.

They did not use hi-tech cryo-protection techniques, simply storing whole testes or bodies in a freezer.

The sperm appeared lifeless when thawed out but researchers were surprised to find that they produced viable offspring.

However, the chances of being able to recreate a woolly mammoth - or at least, an elephant with a woolly mammoth father, are thought to be slim.

Any mammoth recovered from the permafrost would have spent more than 10,000 years in a frozen state.

It would also have been frozen relatively slowly, making it liable to damage from bacteria and other micro-organisms.

Women Crave Support Through IVF Treatment: New Book Jumps to Top of Amazon Rankings

“Nurturing Yourself Through IVF” captures the attention of in vitro fertilization (IVF) patients within 48 hours of being released. (FVNEWSWIRE Jul 7, 2006)

Brampton, ON (FV Newswire) - Within 48 hours of being released on July 1, “Nurturing Yourself Through IVF: Improve Your Experience, Maximize Your Odds of Success” achieved a top-two ranking within a category search for “IVF” on Amazon.com.

Author Lynn Daley is closely familiar with the toll that infertility can take. She believes that the response to the book demonstrates how difficult it can be to get through an IVF cycle.

“Women crave information that can help them feel better; in the case of IVF, they also want to know what can be done to improve their odds of success.”

Daley considers herself an ‘IVF veteran,’ having been through four years of fertility testing and treatment, including two fresh and two frozen IVF cycles. Through her own experience, Daley conducted extensive research (considering both traditional and alternative therapies) and met with more than one hundred women going through IVF.

Because IVF is a medical procedure, it is easy for patients to fall into a clinical mindset. With their lives governed by clinic appointments, drug schedules and lab results, many women find themselves preoccupied with the related numbers, statistics and facts.

As they balance their medical lives with work schedules and social commitments, it can be easy to put aside their own needs. As a result, many women focus on simply ‘getting through’ a cycle, rather than making their emotional health a priority.

“Nurturing Yourself Through IVF” now joins a handful of IVF-specific resources to help women put themselves first through this difficult time. The book draws on the principles of the mind-body connection and directs readers to a wide range of valuable resources.

“A handbook, a companion, a reminder that you are not alone in this, Lynn Daley brings her hard earned compassion to help others take out the suffering in this trying journey toward parenthood.” - Randine Lewis, PhD, author of “The Infertility Cure”

“Nurturing Yourself Through IVF” is available through www.nurturingthroughivf.com, at Amazon, Barnes and Noble, Chapters/Indigo and through bookstores nationwide.

For more information about this book, to receive a review copy or to contact author Lynn Daley, please visit www.nurturingthroughivf.com.

Tuesday, August 15, 2006

Stop scaring older mums

When I entered my forties, I was worried sick that I wouldn't be able to have children. And when I had my first, at 41, I was equally anxious that she would be an only child. I wouldn't wish that stress and worry on any other woman.

I realise that I am incredibly lucky to have had two such beautiful, healthy children - Molly Mae, almost two, and 10-month-old Danny - at an age when successful conception and birth are undoubtedly harder to achieve. But still, it makes me sad how little of their adulthood I'm going to see. It is by no means ideal to start a family as late as I have.

Yesterday, Dr Susan Bewley of Guy's and St Thomas' Hospital described middle-aged mothers as more of a burden to society than teenage mums. Women who delay having children until they are 35 or over constitute a "major public health issue", she said, citing the added cost to the NHS of IVF attempts, miscarriages and premature births - all more likely in older women than their younger sisters. I know the women, these "selfish" older mothers, that Dr Bewley is talking about. She is talking about my friends and I.

Yet, no matter how much I wish that I had met my husband, Jason McCue, a lawyer and the father of my children, at the age of 30 or 34, the fact of the matter is, I did not.

Short of going to a sperm bank, or ending up having a child with someone with whom I had no long-term future, I therefore had no options.

This, of course, is the case for most modern women. Having a child is the most all-consuming thing you can possibly do, and most women really do want to do it with a partner. Yet most of the men I met in my twenties and thirties - and they were by no means exceptional - simply weren't ready to have a long-term, committed relationship, let alone settle down and have kids.

Are we being told, then, that it is better to have a child earlier, with someone unlikely to stick around? I get so angry about these mixed messages. On the one hand we are told that children need a stable family and two parents, and on the other we are continually harangued by people like Dr Bewley for waiting until we have got to a stage where we are more likely to have just that stability.

Surveys show that 34 per cent of women cite the absence of the right bloke as the prime reason for not having children until they are over 35. When it comes to my immediate circle of friends, you can up that figure to 90 per cent.

What truly irritates me about the people who lecture women on their fertility and age is the fact that they apparently watch the world radically change around them, but still hang on to pre-war sensibilities.

If a woman goes out in her twenties looking, with deadly seriousness, for potential father material, she'll be very much on her own. Society no longer expects women to flee the parental nest and almost immediately feather one of their own, and a good thing, too. The boys aren't thinking about starting families in their twenties and neither, to a large extent, are the girls.

Of course, there's another factor at work here, too. For most women, as soon as you have children, your career comes to a standstill at best, or simply goes into reverse. What astonishes me, mind you, is the instant assumption, and continual assertion, that this country is made up of women who are out there burning with ambition, and who are determined not to let anything thwart that ambition (certainly not the arrival of children).

These are the mythical women who, it seems, set out cynically to take advantage of NHS maternity services once they are into their forties and have forged these amazing careers. So - how many women like that do you know?

The truth is much simpler. In order to support children, or even a mortgage, most families find that both parents need to work. Women have to be concerned with making a living. Again, we have no choice. It's hardly "selfish", having worked damn hard for, say, 10 years, to then want to sustain that career rather than watch it crumble at the first sign of a pregnancy bump.

Yes, we have to live in the real world. Many of my friends who ended up having kids in their late thirties or forties did throw caution to the wind in terms of their careers. They knew that time was running out and they couldn't wait any longer for the right moment to take a break.

I remember thinking something like that myself. If having children was going to have a dramatic and negative impact on my career - as a TV arts presenter and Radio 4 journalist - then, you know what, so be it.

If you're a realist, you know it's going to happen - and to an extent, I found that it did. I had a producer on a programme tell me, for example, that my breastfeeding was " inconvenient".

I couldn't go off and film for 12 hours a day, you see, because I had to go home and feed my daughter at certain intervals. And that's working in television, a fairly flexible environment where you'd hope views might be slightly more enlightened. You can imagine the argument we had.

So, of course, it's not women who have to change their behaviour, but the whole of society. If we could guarantee a career break for babies without penalty, then that would be wonderful. At the moment it just doesn't happen.

In my view, it's opinions like those of Dr Bewley that really highlight the lack of understanding of how modern women live. She has said before that women "defy nature" by delaying conception and then relying upon IVF, yet science is defying nature in every way and for incredibly beneficial purposes. Do we not defy nature when we conquer inherited genetic conditions or disease? Advances in science are there to be taken advantage of.

And when she now says that "middle-aged" motherhood costs the NHS more than do teenage mums, well, what's the NHS for? Surely it, too, has to change with society. There are no statistics to back up her argument, since no one seems to know how much "delaying" motherhood actually does cost the NHS.

I would love to see the figures. I would also like to compare them with the costs incurred by 17-year-old mums who, having had a baby so young, find it hard to get a job or start a career, and are thus reliant on other state agencies. Frankly, it's deeply irresponsible to compare older mums with teenage mums on any level at all.

So, let's stop finger-pointing, blaming, and scaring the wits out of older women. By the time you get to your mid-thirties, and in some cases only then, you have at least some idea of what life requires of you. You have matured, and you have far more to offer a tiny human being who is just taking its first steps.

Dr Bewley needs to ask more, much broader, questions, since, if she's not going to find us all the right men at the "ideal" time, she - and the media outlets who interpret her views with such glee - can lecture women until they are blue in the face.

The fact is, we won't be listening.

Keep religion out of stem cell debate

Professor of Medical Genetics at the University of Melbourne, Bob Williamson responds to cabinet's decision to uphold the ban on therapeutic cloning, stopping scientists harvesting embryos to produce stem cells

The Australian Government set up the Lockhart Committee, which was composed of independent experts in law, ethics, religion, medicine and science. They took evidence from hundreds of people and organisations. They weighed the evidence for months, and presented a unanimous report to Government that argues for continuing a strong ban on cloning, but for allowing somatic cell nuclear transfer in the laboratory.

It seems that one of the reasons why the Government is not agreeing to support the Lockhart Committee recommendations is because of the religious beliefs of some members of the Cabinet. We live in a country built by people with many beliefs, and it seems strange that one set of views, followed by a minority even of those who are religious, should have so much impact. While I respect everyone's right to a view on this matter, the value of the research to persons suffering serious illness and handicap is the key issue for Australia. I don't believe that a majority of people in our country want to see our medical research agenda set by religious leaders, rather than by doctors and scientists and patients.

The Australian Academy of Science is one of the many organisations that gave evidence in support of this stance, because on balance we think that there are some scientific questions that can be best answered using this laboratory technique. With Lockhart, we believe that strict legal regulation can maintain the division between what is ethically acceptable because it could lead to dramatic medical progress, and what is totally unacceptable, such as cloning people.

This is now agreed policy in most advanced scientific nations, including the US and the UK, which are actively recruiting our stem cell scientists. During the past few months, two leading Australian scientists, Professors Martin Pera and Paul Simmons, have moved to the United States, in part because of the very restrictive regulatory environment in Australia. To preserve Australia's scientific endeavours in stem cell science, the Commonwealth Government should accept the recommendations of the Lockhart report.

Stem cell therapy is exciting because many diseases are caused when cells either go out of control or die. In cancer patients, cells divide when they shouldn't, while in Alzheimer disease cells in the brain die off prematurely. Cystic fibrosis, an inherited disease affecting young people, has cells that don't move salt around appropriately. One objective of researchers is to use stem cells to treat diseases, as has been done for leukaemia and other blood diseases for many years. Another is to use stem cells to understand why some of these diseases develop, to use either pharmaceutical or lifestyle approaches to reduce their incidence.

Embryo-derived stem cells can make any tissue in the body, and grow forever. However, they are not yet known to be safe for therapy. Isolating them involves destroying "spare" IVF embryos, which is allowed in Australia as in most countries. "Adult" stem cells (which can come from babies, or even a foetus, but are not from early embryos) are safe to use, but tend to form more of the tissue from which they are obtained, and are less flexible.

"Therapeutic cloning" involves transferring the DNA from the cell of an adult (or child) into an egg from which the DNA has been removed, and growing up cells in the lab which are (more or less) between embryonic and adult stem cells in properties. Therapeutic cloning would be particularly valuable for studying diseases we don't understand because the cell doesn't work properly and dies before the patient becomes ill (as for insulin-dependent diabetes of children, and motor neurone disease).

Professor Bob Williamson, who also acts as Chair of the National Committee for Medicine of the Australian Academy of Science, is currently heading a research group that's trying to develop cell therapy for cystic fibrosis using adult stem cells.

Fertility Centers of Illinois (FCI) Offers Free Cycle of IVF Treatment Through Participation in Study of Longer-Lasting Ovary Stimulation Drug

GLENVIEW, Ill.--(BUSINESS WIRE)--Aug. 15, 2006--Fertility Centers of Illinois will offer a free cycle of in-vitro fertilization (IVF) including all medications to as many as 70 patients through its participation in a clinical trial of a new long-lasting drug for ovarian stimulation. Experts are hopeful that this new drug will replace the need for daily injections for patients going through ovulation induction and IVF. FCI performs more than 2,500 IVF cycles each year.

The new drug will enable patients to receive a single injection that will last for seven days versus one injection daily. This modified drug which is a long-lasting recombinant FSH, has already been used in Europe with great success. Before the drug is approved for use in the United States, the Federal Drug and Administration (FDA) requires that a Phase III study be completed for general use among fertility patients. The study will investigate the efficacy of a long-lasting single injection of recombinant FSH to induce multiple follicles for ovarian stimulation in an IVF cycle, compared to daily recombinant FSH.

"FCI is excited about participating in this study as it will give us the opportunity to test the new drug and receive direct feedback from our IVF patients," says Meike Uhler, M.D., a reproductive endocrinologist with Fertility Centers of Illinois. "This study will also allow us to offer a free IVF cycle and medications, making it more affordable for patients to have the treatment." According to Dr. Uhler the average IVF cycle can cost up to $15,000.

IVF patients who meet certain criteria will need to be seen for an initial consultation by an FCI physician at one of their nine satellite offices. If accepted into the study, all monitoring during the IVF cycle must be done at FCI's River North IVF Center.

FCI cannot deviate from the following strict criteria for inclusion and exclusion in the study, which have been established by the pharmaceutical company.

Patients who will be considered as candidates for the study needs to:

-- Have an indication for IVF/ICSI

-- Be 18 - 36 years of age at the time of signing the informed consent form

-- Have a body weight of 132 lb - 198 lb and BMI of 18 - 29

-- Have normal menstrual cycle length of 24 - 35 days

-- Have ejaculatory sperm (donor semen and/or cryopreserved semen is allowed)

Patients who have the following conditions will not be considered as candidates for the study:

-- History of any endocrine abnormality other than ovulatory dysfunction

-- History of Ovarian Hyperstimulation Syndrome

-- History of PCOS

-- Antral Follicle Count greater than 20 follicles less than 11mm (both ovaries combined, measured in menstrual cycle day 2 - 5)

-- Less than 2 ovaries or any ovarian abnormality (including endometrioma greater than 10mm)

-- Presence of hydrosalpinx

-- Presence of clinically relevant pathology of the uterine cavity or fibroids greater than or equal to 5cm

-- More than 3 unsuccessful IVF cycles or recurrent miscarriage since the last established ongoing pregnancy (if applicable)

-- History of poor response to Controlled Ovarian Hyper Stimulation (COHS)

-- FSH or LH greater than 12IU/L as measured by local lab (sample taken menstrual cycle day 2 - 5)

-- Any clinically relevant abnormal lab value based on a sample taken during the screening phase

-- Recent history of epilepsy, HIV, diabetes, cardiovascular, GI, hepatic, renal or pulmonary disease

-- Abnormal karyotype of patient or partner (if performed)

-- Smoking more than 5 cigarettes day

-- History of substance abuse within 12 months prior to signing informed consent

-- Use of hormonal preparations within 1 month prior to randomization (patients may not take OCP's in cycle prior to stimulation cycle)

-- Hypersensitivity to any of the concomitant medication prescribed as part of the treatment regimen of this protocol

-- Pre-Implantation Genetic Diagnosis (PGD)

Candidates interested in applying for the study should call FCI at 1.847.998.8200 and ask for Dr. Aaron Lifchez, Principal Investigator. Candidates will then be contacted by FCI.

About Fertility Centers of Illinois

Fertility Centers of Illinois, S.C., is one of the nation's leading infertility treatment practices, providing advanced reproductive endocrinology services in the Chicago area for over 25 years. FCI performs more IVF than the next nine clinics combined, over 2,500 cycles per year. FCI has more babies born than the next ten centers combined with high success rates that are recognized throughout the nation. In addition to a team of nationally recognized reproductive physicians who collaborate with each other to stay current on the latest technology and procedures, FCI patients have access to many other unique support services such as professional counseling from a licensed, Ph.D. clinical psychologist, patient advocates and innovative financial options. FCI's multiple offices are conveniently located throughout the Chicago area. FCI is part of IntegraMed, the nation's largest and most reputable network of fertility centers. With nearly 160 fertility specialists and scientists in 87 locations across the US, IntegraMed practices have collectively done more research in the field of reproductive medicine and treated more patients than any other physician consortium.

Contacts
Fertility Centers of Illinois (FCI)
Nadine Sudnick, 630-231-7649
nadinesudnick@aol.com